Publications

Publications Libary

A multicenter, randomized, doubleblind, placebo-controlled ascending dose study to evaluate the safety, tolerability..., 2024

Comparative Analysis of Posiphen Pharmacokinetics across Different Species - Similar Absorption and Metabolism..., 2024

Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer’s and..., 2022

Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression, 2021

Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse..., 2020

Translational inhibition of α-synuclein by Posiphen normalizes distal colon motility in transgenic Parkinson mice, 2019

Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons..., 2019

Sequential combined Treatment of Pifithrin-α and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke, 2018

Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse, 2018

Posiphen reverses behavioral deficits and neuropathology in a rat model of mild traumatic brain injury, 2016

Constitutive translation of human α-synuclein is mediated by the 5'-untranslated region, 2015

Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and..., 2013

Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels, 2013

Novel 5' Untranslated Region Directed Blockers of Iron Regulatory Protein-1 Dependent Amyloid Precursor Protein Translation, 2013

The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5' Untranslated-Region-Directed Translation Blockers..., 2012

Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels, 2012

The alpha-synuclein 5' untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen, 2011

Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1, 2010

Amyloid Precursor Protein and Alpha Synuclein Translation, Implications for Iron and Inflammation in Neurodegenerative diseases, 2009

Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine, 2007

The Experimental Alzheimer’s Disease Drug Posiphen [(+)-Phenserine] Lowers Amyloid-beta Peptide Levels in Cell Culture and Mice, 2007

Increased App Expression in a Mouse Model of Down’s Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration, 2006

Brain beta-amyloid42 in Mice Treated Orally with Posiphen Tartrate is Significantly Lower than in Vehicle Controls, 2006

An Iron-responsive Element Type II in the 5'-Untranslated Region of the Alzheimer’s Amyloid Precursor Protein Transcript, 2002

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