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Our Mission

Driven by a clear vision, we are working toward a future where neurodegenerative diseases are not a source of fear and despair, but challenges met with resilience and scientifically proven therapies. Our mission is to halt the death of nerve cells, presenting new hope for millions of patients and their families.

Our mission

We strive to stay at the forefront of advancements in medical technology, ensuring that our laboratory is equipped with state-of-the-art instruments and cutting-edge methodologies. This enables us to offer a comprehensive range of tests that meet the evolving needs of healthcare providers and their patients.

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Leslie Alexander

Founder

Meet our Management team

MARIA L. MACCECCHINI, Ph.D.

Founder, President, CEO and Executive Board Member

Dr. Maccecchini founded Annovis in May 2008 to develop better therapeutics for Alzheimer’s, Parkinson’s and other neurodegenerative diseases. Was partner and director of two angel groups, Robin Hood Ventures and MidAtlantic Angel Group; Founder and CEO of Symphony Pharmaceuticals/Annovis a biotech company that sold in 2001 to Transgenomic; General Manager of Bachem Bioscience, the US subsidiary of Bachem AG, Switzerland and Head Molecular Biology Mallinckrodt; Dr. Maccecchini did one postdoc at Caltech and one at the Roche Institute of Immunology, her PhD in biochemistry is from the Biocenter of Basel with a two-year visiting fellowship at The Rockefeller University.

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MARIA L. MACCECCHINI, Ph.D.
Founder, President, CEO and Executive Board Member

CHENG FANG, Ph.D.

Senior VP, Research and Development

Dr. Fang is an accomplished neuroscientist with two decades of experience in neurodegenerative diseases with broad scientific knowledge and hands-on experience. She has a successful track record of scientific publications and contributions. Dr. Fang has deep drug development knowledge with both pre-clinical and clinical development experience.

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CHENG FANG, Ph.D.
Senior VP, Research and Development

MICHAEL CHRISTIE, Ph.D.

Vice President, Process Chemistry

Dr. Christie has spent over 40 years in the pharmaceutical industry, with a focus on process chemistry R&D, pilot plant production and GMP operations. He has held senior management positions in both large (SmithKline, Rhodia, Teva) and mid-size (Cephalon) companies, as well as being the founder of a company providing contract process R&D services (later acquired by ChiRex). Dr. Christie is co-author or co-inventor on several publications and patents. He earned his BS in chemistry from the University of Michigan and his doctorate from MIT.

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MICHAEL CHRISTIE, Ph.D.
Vice President, Process Chemistry

MELISSA GAINES

Senior VP, Clinical Operations

Ms. Gaines is an accomplished clinical research professional with over 20 years’ experience garnered from positions held in academia, contract research organizations and pharmaceutical companies. She has proven abilities in monitoring and management of Phase I to Phase IV clinical trials, specializing in CNS disorders and extending to a broad range of therapeutic indications. Her CNS experience spans from small Phase I and II studies to large global Phase III trials in Alzheimer’s disease, Parkinson’s disease, sleep disorders, and many psychiatric diseases in both adult and pediatric populations. She has demonstrated proven success in leading cross-functional teams as well as driving operational success. In her current role as VP, Clinical Operations she oversees and supports all clinical project activities.

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MELISSA GAINES
Senior VP, Clinical Operations

EVE DAMIANO, MS, RAC

Senior VP, Regulatory Operations

Ms. Damiano has spent over 35 years in the biotechnology sector, focusing on the definition and execution of regulatory strategies and GxP compliance, encompassing early phase development through commercialization. Ms. Damiano has held various senior management positions throughout her career, with experience garnered at companies including Centocor, MedImmune, OraSure Technologies and Vicuron Pharmaceuticals. Ms. Damiano holds an accomplished track record in the definition and execution of regulatory strategies, including the development of innovative solutions and effective management of projects and resources to meet company objectives.

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EVE DAMIANO, MS, RAC
Senior VP, Regulatory Operations

MARK WHITE

Chief Business Officer

Mark White is a seasoned biopharmaceutical leader with over two decades of global and U.S. experience in pharmaceutical and biotech marketing, business development, and strategic leadership. His extensive expertise spans various therapeutic areas, including rheumatology, dermatology, pain, neuroscience, cardiovascular, and rare diseases. Mark has held significant leadership roles at prominent pharmaceutical companies such as Pfizer, Bracco, Abbott, and Bayer. At Annovis, Mark is leading business development and fund raising while driving the commercialization of buntanetap.

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MARK WHITE
Chief Business Officer

SARAH MacCALLUM

Director of Clinical Operations

Sarah MacCallum is an experienced Clinical Project Manager and Registered Nurse, who has spent over a decade building skills in clinical research on a foundation of direct patient care. Her clinical trial background includes neuro-oncology, breast and bowel cancer, cardiology, pediatric organ transplant, and neuromuscular disorders. She has worked at the site, CRO, and sponsor levels in various roles before joining the Annovis Bio team as Senior Clinical Project Manager for Clinical Operations. Sarah received her Bachelor of Science in Nursing from Saint Louis University and a Bachelor of Arts in English from The Ohio State University.

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SARAH MacCALLUM
Director of Clinical Operations

ANDREW WALSH

Vice President, Finance

Mr. Walsh has over 12 years of diverse finance experience at public and private companies. Prior to joining Annovis, Mr. Walsh served as Senior Director, Finance and Treasury at Ocugen, a Nasdaq-listed biotech developing gene and cell therapies. There he provided oversight over all areas of finance, including SEC Reporting, FP&A, as well as Treasury. Andrew also previously served as Director, Treasury and Tax at Potters Industries, a private equity sponsored materials manufacturer. At Potters, he was instrumental in the implementation of a $650M buy-side structure owned by The Jordan Company. Prior to that, Mr. Walsh worked for Potters’ corporate parent, PQ Corporation and was a critical member of a cross-functional team that divested two reportable segments (including Potters), with total enterprise value of over $1.7B. Andrew began his career at KPMG as a member of its tax practice. He holds a B.S. in Accounting from Drexel University, summa cum laude.

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ANDREW WALSH
Vice President, Finance

ALEXANDER MORIN, Ph.D.

Director, Strategic Communications

Dr. Morin is an expert in scientific communications who is passionate about translating complex science into digestible information. He comes from an academic background where he spent several years working on drug discovery projects for traumatic brain injuries. Later, he worked in a CRO helping design studies for different indications. Most recently, Dr. Morin worked at Public Relations agency with multiple biotech clients increasing their visibility and reputation in front of stakeholders. At Annovis, Dr. Morin is driving communications efforts on all fronts ensuring the transparency and quality of the company's messaging.

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ALEXANDER MORIN, Ph.D.
Director, Strategic Communications

Meet our Scientific Advisory Board (SAB)

SIDNEY STRICKLAND, Ph.D.

SAB Chairman

Dr. Strickland is Vice President and Dean for Educational Affairs and Research Professor, Patricia and John Rosenwald Laboratory of Neurobiology and Genetics at Rockefeller University. Dr. Strickland’s laboratory investigates how dysfunction of the circulatory system contributes to Alzheimer’s and other neurodegenerative disorders. He will serve as the Chairman of Annovis Bio’s SAB.

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SIDNEY STRICKLAND, Ph.D.
SAB Chairman

GREGORY PETSKO, Ph.D.

SAB Member

Dr. Petsko is a member of the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences and the American Philosophical Society. His research interests are directed towards understanding the biochemical bases of neurological diseases like Alzheimer’s, Parkinson’s, and ALS discovering treatments (especially by using structure-based drug design), that could therapeutically affect those biochemical targets, and seeing any resulting drug candidates tested in humans. He has also made key contributions to the field of protein crystallography.

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GREGORY PETSKO, Ph.D.
SAB Member

JEFFREY CUMMINGS, M.D.

Chief Medical Advisor and SAB Member

Dr. Cummings completed a neurology residency and a Fellowship in Behavioral Neurology at Boston University, Boston, Massachusetts. US training was followed by a Research Fellowship in Neuropathology and Neuropsychiatry at the National Hospital for Nervous Diseases, Queen Square, London, England. Dr. Cummings was formerly Professor of Neurology and Psychiatry at UCLA, director of the Mary S. Easton Center for Alzheimer’s Disease Research at UCLA and Director of the Cleveland Clinic Lou Ruvo Center.

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JEFFREY CUMMINGS, M.D.
Chief Medical Advisor and SAB Member

Meet our Board of Directors

MICHAEL B. HOFFMAN

Chairman of the Board

Mr. Hoffman is the Founder and Managing Partner of Stone Capital Partners, a private equity firm focused on power and renewable energy. He was Partner of Riverstone, senior managing director at the Blackstone Group and managing director at Smith Barney, Harris Upham & Co. He serves as President of Northern Genesis Acquisition Corporation (II and III) and is a Trustee of The Rockefeller University.

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MICHAEL B. HOFFMAN
Chairman of the Board

MARIA L. MACCECCHINI, Ph.D.

Executive Board Member

Dr. Maccecchini founded Annovis in May 2008 to develop better therapeutics for Alzheimer’s, Parkinson’s and other neurodegenerative diseases. Founder and CEO of Annovis (f.k.a. Symphony Pharmaceuticals) focused on protecting brain cells after stroke. It sold in 2001 to Transgenomic.

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MARIA L. MACCECCHINI, Ph.D.
Executive Board Member

REID S. McCARTHY

Board Member

Mr. McCarthy is experienced in corporate financial management, operations and new venture development. He was CFO of Topaz Pharmaceuticals, Inc. until its sale in 2011 to Sanofi Pasteur. He also served as CFO of JJ Haines & Company, Inc. and provided consulting CFO services to several life sciences companies. He has been a founding executive of several venture capital-backed companies which were successfully sold.

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REID S. McCARTHY
Board Member

CLAUDINE E. BRUCK, Ph.D.

Board Member

Dr. Bruck is a pharmaceutical executive and scientist with a strong entrepreneurial drive. Exhibited successes in building a therapeutic research unit de novo and leading discovery and clinical development of biological (vaccines, biopharmaceuticals) and small molecule medicines as well as an ophthalmic drug portfolio. With creativity and a strong results-focus, she is energized to challenge and lead teams. Extensive Pharmaceutical industry experience spans drug discovery and development across several therapeutic.

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CLAUDINE E. BRUCK, Ph.D.
Board Member

MARK WHITE

Board Member

Mark White is a seasoned biopharmaceutical leader with over two decades of global and U.S. experience in pharmaceutical and biotech marketing, business development, and strategic leadership. His extensive expertise spans various therapeutic areas, including rheumatology, dermatology, pain, neuroscience, cardiovascular, and rare diseases. Mark has held significant leadership roles at prominent pharmaceutical companies such as Pfizer, Bracco, Abbott, and Bayer. At Annovis, Mark is leading business development and fund raising while driving the commercialization of buntanetap.

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MARK WHITE
Board Member

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